Arsenal take on BATE in the second leg of their UEFA Champions League Round of 32 tie at the Emirates Stadium. The Gunners slumped to a disappointing 1-0 defeat in Belarus.
Celtic must overturn a two-goal deficit as they meet Valencia in the UEFA Europa League Round of 32 second leg. Brendan Rodgers' men have picked up just one away win this campaign.
Chelsea welcome Malmo to Stamford Bridge in the second leg of their UEFA Europa League Round of 32 tie. The Blues hold a 2-1 advantage following their victory in Sweden last week.
Inter host Rapid Vienna in the second leg of their UEFA Europa League round of 32 tie at the San Siro.
Benfica and Galatasaray do battle in the second leg of their UEFA Europa League Round of 32 tie.
Action from the top flight in Germany as Werder Bremen welcome Stuttgart to the Weserstadion.
West Ham United take on Fulham at the London Stadium in the Premier League. The Hammers won 2-0 in the reverse fixture at Craven Cottage.
Dundee welcome Hibernian to Dens Park in the Ladbrokes Premiership.
Strasbourg welcome Lille to the Stade de la Meinau in France's top flight.
Burnley entertain Tottenham Hotspur at Turf Moor in the Premier League. A stoppage-time winner from Christian Eriksen saw Spurs win 1-0 in the reverse fixture.
West Bromwich Albion face Sheffield United at The Hawthorns in the Sky Bet Championship. The Baggies were 2-1 winners in the reverse fixture.
Leicester City face Crystal Palace in the Premier League at the King Power Stadium.
Fortuna Dusseldorf and Nuremberg square-off in the Bundesliga at the Merkur Spiel-Arena.
Promotion-chasing Luton take on Coventry City at Kenilworth Road in Sky Bet League 1. Luton won 2-1 when the sides met earlier in the season.
Rangers travel to the Hope CBD Stadium to take on Hamilton in the Ladbrokes Premiership.
Ole Gunnar Solskjaer's Manchester United meet rivals Liverpool at Old Trafford in the Premier League. The reverse fixture ended 3-1 to Liverpool in Jose Mourinho's final United game.
Hannover face Eintracht Frankfurt in the Bundesliga at the HDI-Arena.
Rennes entertain Marseille in Ligue 1 at Roazhon Park.
Chelsea and Manchester City go head-to-head in the Carabao Cup final at Wembley. City are looking to retain the trophy, Chelsea going for a first crown since 2015.
Borussia Dortmund host Bayer Leverkusen at Signal Iduna Park in the Bundesliga.
Monaco and Lyon go head-to-head in Ligue 1 at the Stade Louis II.