With second place secured, Schalke host Lokomotiv Moscow in Group D of the UEFA Champions League at the Veltins-Arena. Lokomotiv haven't won away in this competition since 2002.
Galatasary face Group D winners Porto in the Champions League at the Turk Telekom Stadium. The hosts will clinch a Europa League spot if they win or Lokomotiv fail to beat Schalke.
It's all-or-nothing for Inter Milan as they host already-eliminated PSV Eindhoven in Group B of the UEFA Champions League. Inter are unbeaten in ten matches against Dutch sides.
Liverpool and Napoli meet in a huge UEFA Champions League clash at Anfield with a place in the knockout stages on the line. The Reds must win to stand any chance of progressing.
Tottenham hope to join Barcelona in the last-16 of the UEFA Champions League as the two sides clash at the Nou Camp. A win for Spurs will see them qualify as Group B runners-up.
Group winners Real Madrid take on CSKA Madrid at the Bernabeu Stadium in Group G of the UEFA Champions League. CSKA still harbour hopes of qualifying for the Europa League.
Viktoria Plzen play host to Roma in Group G of the UEFA Champions League at the Doosan Arena. Roma thrashed their hosts 5-0 at the Stadio Olimpico on matchday two.
Young Boys welcome Juventus to the Stade de Suisse in Group G of the UEFA Champions League. The Italian giants need a win or to better Man Utd's result to advance as group winners.
Manchester City play host to Hoffenheim in the UEFA Champions League at the Etihad Stadium. Pep Guardiola's side need just a point to qualify for the next stage as group winners.
Manchester United travel to the Mestalla to take on Valencia in the Champions League. Jose Mourinho's side can top Group H with a win if Juventus slip up at Young Boys.